Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation.
basic_science · Level V
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- Record sourced from PubMed, PMID 17828272.
- Also identified by PMC identifier 5114125.
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Abstract
T(H)17 lymphocytes appear to be essential in the pathogenesis of numerous inflammatory diseases. We demonstrate here the expression of IL-17 and IL-22 receptors on blood-brain barrier endothelial cells (BBB-ECs) in multiple sclerosis lesions, and show that IL-17 and IL-22 disrupt BBB tight junctions in vitro and in vivo. Furthermore, T(H)17 lymphocytes transmigrate efficiently across BBB-ECs, highly express granzyme B, kill human neurons and promote central nervous system inflammation through CD4+ lymphocyte recruitment.
Medical subject headings
- Blood-Brain Barrier
- Central Nervous System
- Inflammation
- T-Lymphocytes, Helper-Inducer