Hyperalgesia and myoclonus with intrathecal infusion of high-dose morphine.

de Conno, Franco; Caraceni, Augusto; Martini, Cinzia; Spoldi, Elio; Salvetti, Monica; Ventafridda, Vittorio · Pain · 1991

case_report · Level V

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Abstract

We report the case of a patient who developed myoclonus and hyperalgesia following administration of high-dose subarachnoid morphine. This complication occurred with 40-80 mg/day continuous infusion. The pathophysiology of these side effects is discussed.

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