The effects of oral morphine and buprenorphine on autotomy following brachial nerve sections in rat.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 1784506.
- Also identified by DOI 10.1016/0304-3959(91)90228-P.
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Abstract
This study assessed the relationship between autotomy and opioid systems following brachial nerve sections in the rat. Morphine, buprenorphine and/or naloxone were self-administered orally to rats following nerve sections. Oral morphine and buprenorphine increased the severity of autotomy. Naloxone alone had no effect, but reversed oral morphine effect on autotomy. These results suggest that mu-receptor activation by morphine and buprenorphine can increase the severity of autotomy.
Medical subject headings
- Brachial Plexus
- Buprenorphine
- Morphine
- Pain
- Self Mutilation