Allele-specific targeting of microRNAs to HLA-G and risk of asthma.
basic_science · Level V
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- Record sourced from PubMed, PMID 17847008.
- Also identified by PMC identifier 2227932.
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Abstract
HLA-G is a nonclassic, class I HLA molecule that has important immunomodulatory properties. Previously, we identified HLA-G as an asthma-susceptibility gene and discovered that the risk of asthma in a child was determined by both the child's HLA-G genotype and the mother's affection status. Here we report a SNP in the 3' untranslated region of HLA-G that influences the targeting of three microRNAs (miRNAs) to this gene, and we suggest that allele-specific targeting of these miRNAs accounts, at least in part, for our earlier observations on HLA-G and the risk of asthma.
Medical subject headings
- Asthma
- HLA Antigens
- Histocompatibility Antigens Class I
- MicroRNAs