Hydrogel nanocomposites as remote-controlled biomaterials.
basic_science · Level V
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- Record sourced from PubMed, PMID 17855176.
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Abstract
Nanocomposite hydrogels are a new class of intelligent materials which have recently attracted interest as biomaterials. In this study, magnetic nanocomposites of temperature-sensitive hydrogels have been developed and demonstrated to be responsive to alternating magnetic fields. Nanocomposites were synthesized by incorporation of superparamagnetic Fe(3)O(4) particles in negative temperature-sensitive poly(N-isopropylacrylamide) hydrogels. The systems were characterized for temperature-responsive swelling, remote heating on application of an alternating magnetic field and remote-controlled drug delivery applications. The rise in temperature in external alternating magnetic field depends on the Fe(3)O(4) particle loading of the system. Preliminary studies on remote-controlled drug release showed reduced release in the presence of an alternating magnetic field.
Medical subject headings
- Biocompatible Materials
- Delayed-Action Preparations
- Drug Carriers
- Hydrogels
- Nanocomposites