The IL23 axis plays a key role in the pathogenesis of IBD.
basic_science · Level V
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- Record sourced from PubMed, PMID 17872562.
- Also identified by PMC identifier 2000291.
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Abstract
Exciting new results from a genetic study in humans and functional studies in mice have pinpointed interleukin 23 (IL23) and its receptor as a key pathway in the pathogenesis of inflammatory bowel disease (IBD). These findings reveal a hitherto unappreciated role for the IL23 axis in intestinal inflammation and may open new avenues for development of therapeutic strategies in IBD.
Medical subject headings
- Inflammatory Bowel Diseases
- Interleukin-23