Labeling of mesenchymal stem cells by bioconjugated quantum dots.
basic_science · Level V
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- Record sourced from PubMed, PMID 17887799.
- Also identified by PMC identifier 4410692.
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Abstract
Long-term labeling of stem cells during self-replication and differentiation benefits investigations of development and tissue regeneration. We report the labeling of human mesenchymal stem cells (hMSCs) with RGD-conjugated quantum dots (QDs) during self-replication, and multilineage differentiations into osteogenic, chondrogenic, and adipogenic cells. QD-labeled hMSCs remained viable as unlabeled hMSCs from the same subpopulation. These findings suggest the use of bioconjugated QDs as an effective probe for long-term labeling of stem cells.
Medical subject headings
- Image Enhancement
- Mesenchymal Stem Cells
- Microscopy, Fluorescence
- Oligopeptides
- Quantum Dots