Non-oncogene addiction and the stress phenotype of cancer cells.
editorial · Level V
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Abstract
Heat-shock factor 1 (HSF1) is a transcription factor that is activated upon proteotoxic stress and coordinates induction of the heat-shock response. In this issue, Dai et al. (2007) show that HSF1 is a potent modifier of tumorigenesis and is required for tumor initiation and maintenance in a variety of cancer models. These findings add HSF1 to a growing list of non-oncogenes that could be exploited as cancer drug targets.
Medical subject headings
- Cell Transformation, Neoplastic
- DNA-Binding Proteins
- Gene Expression Regulation, Neoplastic
- Skin
- Skin Neoplasms
- Stress, Physiological
- Transcription Factors