Endocytosis of neurotransmitter receptors: location matters.
review · Level V
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Abstract
Endocytosis of excitatory glutamate receptors from the postsynaptic plasma membrane plays a fundamental role in synaptic function and plasticity. In a recent study published in Neuron, Lu et al. (2007) describe protein interactions that link zones of receptor endocytosis directly to the postsynaptic scaffold and propose that local trafficking of receptors facilitated by these endocytic zones is required to maintain synaptic responsiveness.
Medical subject headings
- Clathrin
- Clathrin-Coated Vesicles
- Coated Pits, Cell-Membrane
- Endocytosis
- Neuronal Plasticity
- Receptors, AMPA
- Synapses