Nighttime levodopa infusions to treat motor fluctuations in advanced Parkinson's disease: preliminary observations.
case_report · Level V
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Abstract
We report the clinical response of a parkinsonian patient with severe motor fluctuations who was begun on continuous, nighttime-only levodopa infusions accompanied by oral carbidopa/levodopa use during the day. Sleep disturbances improved immediately. There was a gradual reduction in "off" time and severity of dyskinesias during the waking day. Nighttime-only levodopa infusions have a carryover benefit to the waking hours and may be suitable for long-term therapy to reduce daily motor fluctuations in some patients with Parkinson's disease.
Medical subject headings
- Levodopa
- Movement Disorders
- Parkinson Disease