Decoding protein modifications using top-down mass spectrometry.
review · Level V
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- Record sourced from PubMed, PMID 17901871.
- Also identified by PMC identifier 2365886.
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Abstract
Top-down mass spectrometry is an emerging technology which strives to preserve the post-translationally modified forms of proteins present in vivo by measuring them intact, rather than measuring peptides produced from them by proteolysis. The top-down technology is beginning to capture the interest of biologists and mass spectrometrists alike, with a main goal of deciphering interaction networks operative in cellular pathways. Here we outline recent approaches and applications of top-down mass spectrometry as well as an outlook for its future.
Medical subject headings
- Mass Spectrometry
- Proteomics