Neurokinin-1 receptor antagonists as novel antidepressants: trials and tribulations.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 17906236.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Based upon animal experiments and early clinical trials, neurokinin-1 receptor antagonists showed promise as novel antidepressants. Subsequently, however, more extensive clinical trials did not reveal evidence of efficacy in depression. The development of novel antidepressants will require a better understanding of the neural basis of antidepressant action in humans.
Medical subject headings
- Antidepressive Agents
- Depressive Disorder
- Drug Design
- Morpholines
- Neurokinin-1 Receptor Antagonists