Silencing insulin resistance through SIRT1.
editorial · Level V
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Abstract
Insulin resistance is an important risk factor for the development of type 2 diabetes and the metabolic syndrome. A new study in this issue of Cell Metabolism (Sun et al., 2007) shows that SIRT1, a mammalian sirtuin homolog and histone deacetylase, can ameliorate insulin resistance by silencing expression of protein tyrosine phosphatase 1B, a major negative regulator of insulin action.
Medical subject headings
- Gene Silencing
- Insulin Resistance
- Protein Tyrosine Phosphatase, Non-Receptor Type 1
- Sirtuins