Does FASing out new fat in the hypothalamus make you slim?
basic_science · Level V
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- Record sourced from PubMed, PMID 17908552.
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Abstract
Fatty acid synthase (FAS) is a key enzyme for lipogenesis. A recent study (Chakravarthy et al., 2007) shows that the targeted deletion of FAS in hypothalamic neurons produces hypophagic, lean mice and suggests that PPARalpha signaling is an important mediator of the effects of FAS on energy homeostasis.
Medical subject headings
- Fatty Acid Synthases
- Hypothalamus
- Obesity
- Weight Loss