Neuronal glucose sensing: still a physiological orphan?
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Abstract
Although hypothalamic glucose sensing is a long-established phenomenon, its physiological role remains unclear. New studies (Parton et al., 2007; Claret et al., 2007) disrupting glucose sensing in pro-opiomelanocortin neurons via differing methods have yielded disparate energy and glucose homeostasis phenotypes, suggesting that neuronal glucose sensing is not critical for these processes.
Medical subject headings
- Glucose
- Hypothalamus
- Neurons
- Pro-Opiomelanocortin