Estrogen and bone: osteoclasts take center stage.
basic_science · Level V
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Abstract
Loss of estrogen at menopause causes osteoporosis in many women, but estrogen's relevant cellular target in this process has remained unclear. In a recent study in Cell, Kato and colleagues (Nakamura et al., 2007) selectively ablate estrogen receptor alpha in osteoclasts and demonstrate that estrogen directly induces osteoclast apoptosis.
Medical subject headings
- Bone and Bones
- Estrogen Receptor alpha
- Estrogens
- Osteoclasts
- Osteoporosis, Postmenopausal