Nipping at cardiac remodeling.
Level V
Where this comes from
- Record sourced from PubMed, PMID 17909620.
- Also identified by PMC identifier 1994642.
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Abstract
Much of the mortality following myocardial infarction results from remodeling of the heart after the acute ischemic event. Cardiomyocyte apoptosis has been thought to play a key role in this remodeling process. In this issue of the JCI, Diwan and colleagues present evidence that Bnip3, a proapoptotic Bcl2 family protein, mediates cardiac enlargement, reshaping, and dysfunction in mice without influencing infarct size.
Medical subject headings
- Cardiac Output, Low
- Membrane Proteins
- Myocardial Infarction
- Myocytes, Cardiac
- Proto-Oncogene Proteins
- Ventricular Remodeling