microRNAs join the p53 network--another piece in the tumour-suppression puzzle.
review · Level V
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- Record sourced from PubMed, PMID 17914404.
- Also identified by DOI 10.1038/nrc2232 and PMC identifier 4053212.
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Abstract
Several recent studies have found a conserved microRNA (miRNA) family, the miR-34s, to be direct transcriptional targets of p53. miR-34 activation can recapitulate elements of p53 activity, including induction of cell-cycle arrest and promotion of apoptosis, and loss of miR-34 can impair p53-mediated cell death. These data reinforce the growing awareness that non-coding RNAs are key players in tumour development by placing miRNAs in a central role in a well-known tumour-suppressor network.
Medical subject headings
- Cell Transformation, Neoplastic
- Gene Expression Regulation
- MicroRNAs
- Tumor Suppressor Protein p53