Retrovirus silencing by an epigenetic TRIM.
basic_science · Level V
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Abstract
Embryonic cells silence transcription by retroviruses, but how do they recognize virus DNA? In this issue, Wolf and Goff (2007) report that a TRIM28 corepressor complex binds to the retrovirus primer binding site. Epigenetic silencing of retrovirus transcription is accomplished by "writing" a dimethyl mark on lysine 9 of histone H3 that is read by the heterochromatin protein HP1gamma.
Medical subject headings
- Embryonic Stem Cells
- Epigenesis, Genetic
- Gene Silencing
- Nuclear Proteins
- Repressor Proteins
- Retroviridae
- Transcription Factors