How to assemble a capsid.
basic_science · Level V
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- Record sourced from PubMed, PMID 17923081.
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Abstract
Retroviral capsids are composed of hexagonal arrays of the viral CA protein. In this issue of Cell, Ganser-Pornillos et al. (2007) provide a molecular model of the hexagonal HIV-1 CA lattice obtained from a new electron cryomicroscopic reconstruction. This study reveals the three principal stabilizing interfaces in the capsid lattice and explains how two different classes of inhibitors can block capsid assembly.
Medical subject headings
- Capsid
- Capsid Proteins
- Protein Structure, Quaternary