The impact of a negligent G2/M checkpoint on genomic instability and cancer induction.
review · Level V
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- Record sourced from PubMed, PMID 17943134.
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Abstract
DNA damage responses (DDR) encompass DNA repair and signal transduction pathways that effect cell cycle checkpoint arrest and/or apoptosis. How DDR pathways respond to low levels of DNA damage, including low doses of ionizing radiation, is crucial for assessing environmental cancer risk. It has been assumed that damage-induced cell cycle checkpoints respond to a single double strand break (DSB) but the G2/M checkpoint, which prevents entry into mitosis, has recently been shown to have a defined threshold of 10-20 DSBs. Here, we consider the impact of a negligent G2/M checkpoint on genomic stability and cancer risk.
Medical subject headings
- Cell Cycle Proteins
- Cell Division
- Cell Transformation, Neoplastic
- DNA Damage
- DNA Repair
- DNA-Binding Proteins
- G2 Phase
- Genomic Instability
- Protein Serine-Threonine Kinases
- Tumor Suppressor Proteins