Thrombotic microangiopathy and the antiphospholipid antibody syndrome.

Durand, J M; Lefevre, P; Kaplanski, G; Soubeyrand, J · J Rheumatol · 1991

case_report · Level V

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Abstract

A 23-year-old woman with the antiphospholipid syndrome developed severe thrombocytopenia (14 x 10(9)/l) and microangiopathic hemolytic anemia after plasma exchange. A relation was suspected between rising anticardiolipin level and development of thrombotic microangiopathy. The mechanism responsible may be interference between anticardiolipin antibody, platelet membrane and endothelial cell.

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