Challenges in pulmonary fibrosis x 5: the NSIP/UIP debate.
review · Level V
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- Record sourced from PubMed, PMID 17965079.
- Also identified by PMC identifier 2117119.
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Abstract
Among the idiopathic interstitial pneumonias, the two entities-idiopathic pulmonary fibrosis (IPF) characterised by the presence of the usual interstitial pneumonia pattern of histopathology (IPF/UIP) and non-specific interstitial pneumonia (NSIP; same nomenclature for the histopathological pattern and idiopathic disease) - have provoked considerable debate. IPF/UIP and NSIP closely mimic each other clinically but NSIP has a far better outcome. However, it remains unclear if NSIP is a truly separate and distinct entity. The histopathological pattern of NSIP can be found in a wide variety of clinical and radiological contexts. This review addresses these and other uncertainties regarding NSIP and UIP.
Medical subject headings
- Lung
- Lung Diseases, Interstitial
- Pulmonary Fibrosis