Psychosis in a 12-year-old HIV-positive girl with an increased serum concentration of efavirenz.
case_report · Level V
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- Record sourced from PubMed, PMID 17968817.
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Abstract
Clearance and adverse effects of efavirenz are associated with CYP2B6-G516T polymorphism. Little is known about the prevalence of genotypes and implications for screening in children. We report (to our knowledge, for the first time in a child) the emergence of psychosis in a 12-year old white girl with an increased efavirenz concentration and heterozygous gene polymorphism of the CYP2B6-G516T.
Medical subject headings
- Benzoxazines
- HIV Infections
- Psychoses, Substance-Induced
- Reverse Transcriptase Inhibitors