Nampt/PBEF/Visfatin: a new player in beta cell physiology and in metabolic diseases?
editorial · Level V
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Abstract
NAD plays an essential role in a number of biological processes. A study in this issue of Cell Metabolism (Revollo et al., 2007b) demonstrates that nicotinamide phosphoribosyltransferase (Nampt), also known as PBEF or visfatin, is a secreted enzyme and a source of systemic NAD. The authors show that Nampt-mediated NAD synthesis is necessary for beta cell function, providing fresh insights into the pathophysiology of metabolic diseases.
Medical subject headings
- Insulin-Secreting Cells
- Metabolic Diseases
- Nicotinamide Phosphoribosyltransferase