DisSIRTing on LXR and cholesterol metabolism.
editorial · Level V
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Abstract
The NAD-dependent deacetylase SIRT1 regulates lipid and carbohydrate metabolism and has been shown to extend life span in several species. In a recent issue of Molecular Cell, Li et al. (2007) demonstrate that SIRT1 deacetylates and activates the nuclear receptor LXR by favoring its ligand-dependent proteasomal degradation, thereby potentially regulating reverse cholesterol transport.
Medical subject headings
- Cholesterol
- Receptors, Cytoplasmic and Nuclear
- Sirtuins