Oligonucleotide loading determines cellular uptake of DNA-modified gold nanoparticles.
basic_science · Level V
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- Record sourced from PubMed, PMID 17997588.
- Also identified by PMC identifier 8585332.
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Abstract
The cellular internalization of oligonucleotide-modified nanoparticles is investigated. Uptake is dependent on the density of the oligonucleotide loading on the surface of the particles, where higher densities lead to greater uptake. Densely functionalized nanoparticles adsorb a large number of proteins on the nanoparticle surface. Nanoparticle uptake is greatest where a large number of proteins are associated with the particle.
Medical subject headings
- DNA
- Gold
- Nanoparticles
- Oligodeoxyribonucleotides