RecBCD: the supercar of DNA repair.
basic_science · Level V
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- Record sourced from PubMed, PMID 18022359.
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Abstract
The DNA helicase RecBCD pauses when it reaches recombination hotspots known as Chi sites and then proceeds at a slower speed of translocation than before Chi recognition. Reporting in this issue, Spies et al. (2007) now show that this reduction in translocation velocity occurs when RecBCD changes which of its two motor subunits is in the lead.
Medical subject headings
- DNA Repair
- Exodeoxyribonuclease V