Identification of DNA basepairing via tunnel-current decay.
basic_science · Level V
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- Record sourced from PubMed, PMID 18041859.
- Also identified by PMC identifier 2311509.
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Abstract
We propose a new approach for reading the sequence of a DNA molecule passing between electrodes on a nanopore, using hydrogen bond-mediated tunneling signals. The base-electrode interaction is modeled using a nucleo-base-functionalized STM probe that is pulled away from a nucleoside monolayer. Watson-Crick recognition results in slow decay of the tunnel current, which is uniquely characteristic of the basepair in over half the reads. Thirteen independent reads would yield the desired 99.99% accuracy.
Medical subject headings
- Base Pairing
- DNA