DNA mismanagement leads to immune system oversight.
basic_science · Level V
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- Record sourced from PubMed, PMID 18045527.
- Also identified by PMC identifier 3527077.
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Abstract
Trex1, a major 3' DNA exonuclease in mammalian cells, has been thought to act primarily in DNA replication or repair. Surprisingly, the major phenotype resulting from Trex1 deficiency in humans and mice is a chronic inflammatory disease. In this issue, Yang et al. (2007) report that Trex1 deficiency causes chronic activation of the ATM-dependent DNA-damage checkpoint and accumulation of a discrete single-stranded DNA species in the cytoplasm, either of which could contribute to chronic inflammation.
Medical subject headings
- Autoimmunity
- DNA Damage
- Immune System