Supersensitivity to isoprenaline induced in cultured neonatal rat heart cells by certain eicosatetraenoic acids.
basic_science · Level V
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Abstract
Among a number of racemic eicosatetraenoic acids (HETEs) investigated, 15-R/S HETE and 11-R/S-HETE were the only ones that enormously potentiated the chronotropic action of isoprenaline on neonatal rat heart myocytes in rocked culture. The effect of the 15-R/S-HETE was exclusively due to the S isomer.
Medical subject headings
- Arachidonic Acids
- Heart
- Isoproterenol