Genetics of melanoma tumorigenesis.

Singh, M; Lin, J; Hocker, T L; Tsao, H · Br J Dermatol · 2008

review · Level V

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Abstract

Melanoma therapy is moving away from combinatorial approaches and towards newer targeted strategies. With the identification of mutations in various RAS pathway genes, there are now tremendous opportunities to bring inhibitors of RAS signalling to the clinical arena.

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