Bisphosphonates and avascular necrosis of the mandible: case report and review of the literature.

Murray, Dylan J; Vesely, Martin J J; Novak, Christine B; Irish, Jonathan; Crump, Michael; Neligan, Peter C · J Plast Reconstr Aesthet Surg · 2008

case_report · Level V

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Abstract

Avascular necrosis of the mandible or maxilla is being recognized with increasing frequency in patients who are being treated with bisphosphonates for metastatic cancers. A patient who was treated for avascular necrosis following treatment with bisphosphonates for multiple myeloma is presented. Prophylactic and preventative measures should be instituted prior to commencing treatment with bisphosphonates to minimize the risk of developing avascular necrosis.

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