TAMpering with toll-like receptor signaling.
editorial · Level V
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Abstract
Toll-like receptors (TLRs) provoke a profound inflammatory response during host defense and must be controlled in order to avoid autoimmune and inflammatory diseases. In this issue, Rothlin et al. (2007) uncover a complex negative feedback mechanism to limit TLR signaling involving the Tyro3/Axl/Mer (TAM) family of receptor tyrosine kinases, which induce expression of the inhibitory proteins SOCS1 and SOCS3.
Medical subject headings
- Receptor Protein-Tyrosine Kinases
- Toll-Like Receptors