Integrating spatially resolved three-dimensional MALDI IMS with in vivo magnetic resonance imaging.
basic_science · Level V
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- Record sourced from PubMed, PMID 18084298.
- Also identified by PMC identifier 2649801.
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Abstract
We have developed a method for integrating three dimensional-volume reconstructions of spatially resolved matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS) ion images of whole mouse heads with high-resolution images from other modalities in an animal-specific manner. This approach enabled us to analyze proteomic profiles from MALDI IMS data with corresponding in vivo data provided by magnetic resonance imaging.
Medical subject headings
- Brain
- Imaging, Three-Dimensional
- Magnetic Resonance Imaging
- Peptide Mapping
- Proteome
- Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization