Universal scaling law of electrical turbulence in the mammalian heart.
basic_science · Level V
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- Record sourced from PubMed, PMID 18093948.
- Also identified by PMC identifier 2409253.
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Abstract
Many biological processes, such as metabolic rate and life span, scale with body mass (BM) according to the universal law of allometric scaling: Y = aBM(b) (Y, biological process; b, scaling exponent). We investigated whether the temporal properties of ventricular fibrillation (VF), the major cause of sudden and unexpected cardiac death, scale with BM. By using high-resolution optical mapping, numerical simulations and metaanalysis of VF data in 11 mammalian species, we demonstrate that the interbeat interval of VF scales as VF(cycle) (length) = 53 x BM(1/4), spanning more than four orders of magnitude in BM from mouse to horse.
Medical subject headings
- Electrocardiography
- Heart Conduction System
- Ventricular Fibrillation