Macular choroidal occlusion in dysplasminogenemia.

Yamaguchi, K; Abe, S; Shiono, T; Kimizuka, Y; Hara, S; Tamai, M; Sugai, K; Mori, K · Retina · 1991

case_report · Level V

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Abstract

The authors describe a family with dysplasminogenemia. This diagnosis was based on a lowered ratio of functional plasminogen activity to immunologic plasminogen antigen level, associated with fundus abnormalities. The proband is a 31-year-old woman with Graves disease who had choroidal occlusive lesions of the macula in both eyes. The results of the laboratory examination indicated that the patient was a homozygote for dysplasminogenemia. Similar examinations of the patient's parents and siblings showed their plasminogen levels to be 50% below normal. The thrombotic tendency in this disorder appeared to be responsible for the pathogenesis of the macular choroidal occlusion.

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