A dead end for microRNAs.
editorial · Level V
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Abstract
Dead end (Dnd1) is an RNA-binding protein that mediates germ-cell viability and suppresses the formation of germ-cell tumors. Kedde et al. (2007) now provide evidence that Dnd1 mediates these effects by counteracting microRNA-mediated silencing of mRNAs.
Medical subject headings
- Gene Expression Regulation, Developmental
- Gene Silencing
- Germ Cells
- MicroRNAs
- RNA, Messenger
- RNA-Binding Proteins
- Transcription, Genetic
- Zebrafish Proteins