Template switching: from replication fork repair to genome rearrangements.
basic_science · Level V
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Abstract
Genome rearrangements are a hallmark of human genomic disorders and occur largely through recombination mechanisms. In this issue, Lee et al. (2007) show that the complex nonrecurrent rearrangements observed in the dysmyelinating disorder Pelizaeus-Merzbacher disease (PMD) are likely to be caused by a replication mechanism involving template switching.
Medical subject headings
- DNA Replication
- Gene Deletion
- Gene Duplication
- Gene Rearrangement
- Membrane Proteins
- Myelin Proteolipid Protein
- Pelizaeus-Merzbacher Disease
- Recombination, Genetic