Next-generation sequencing transforms today's biology.

Schuster, Stephan C · Nat Methods · 2008

review · Level V

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Abstract

A new generation of non-Sanger-based sequencing technologies has delivered on its promise of sequencing DNA at unprecedented speed, thereby enabling impressive scientific achievements and novel biological applications. However, before stepping into the limelight, next-generation sequencing had to overcome the inertia of a field that relied on Sanger-sequencing for 30 years.

Medical subject headings