Renoprotection with vitamin D: specific for diabetic nephropathy?
basic_science · Level V
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- Record sourced from PubMed, PMID 18165810.
- Also identified by DOI 10.1038/sj.ki.5002693.
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Abstract
Zhang and co-workers report on the renoprotective role of the vitamin D receptor (VDR) in diabetic nephropathy using the method of streptozotocin-induced hyperglycemia in wild-type and VDR(-/-) mice. Also, experiments with cultured mesangial cells and podocytes confirm the effect of the active vitamin D metabolite 1,25(OH)(2)D(3) on inhibition of the renin-angiotensin system (RAS) in vitro. The authors conclude that the higher activation of the intrarenal RAS is the key factor to induce more severe diabetic nephropathy in VDR(-/-) mice.
Medical subject headings
- Diabetic Nephropathies
- Receptors, Calcitriol
- Vitamin D