Silencing metabolic disorders by novel SIRT1 activators.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18177718.
- Also identified by DOI 10.1016/j.cmet.2007.12.005.
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Abstract
SIRT1, a NAD(+)-dependent protein deacetylase that regulates transcription factors involved in key cellular processes, has been implicated as a mediator of the beneficial effects of calorie restriction. In a recent issue of Nature, Milne et al. (2007) describe novel potent activators of SIRT1, whose administration to insulin-resistant animals improves glucose homeostasis.
Medical subject headings
- Metabolic Diseases
- Sirtuins