Fluxing the mitochondria to insulin resistance.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 18177719.
- Also identified by DOI 10.1016/j.cmet.2007.12.002.
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Abstract
Elevated fatty acids promote inflammation and insulin resistance. In this issue of Cell Metabolism, Koves et al. (2008) explore a novel paradigm suggesting that beta-oxidation of fatty acids exceeding the capacity of the tricarboxylic acid cycle yields incomplete fat oxidation and mitochondrial distress, obligatory events in the pathogenesis of insulin resistance.
Medical subject headings
- Insulin Resistance
- Mitochondria