A deletion in the chemokine receptor 5 (CCR5) gene is associated with tickborne encephalitis.
case_control · Level III
Where this comes from
- Record sourced from PubMed, PMID 18179389.
- Also identified by DOI 10.1086/524709.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Tickborne encephalitis (TBE) virus infections can be asymptomatic or cause moderate to severe injuries of the central nervous system. Why some individuals develop severe disease is unknown, but a role for host genetic factors has been suggested. To investigate whether chemokine receptor CCR5 is associated with TBE, CCR5Delta32 genotyping was performed among Lithuanian patients with TBE (n=129) or with aseptic meningoencephalitis (n=76) as well as among control subjects (n=134). We found individuals homozygous for CCR5Delta32 (P= .026) only among patients with TBE and a higher allele prevalence among patients with TBE compared with the other groups studied. CCR5Delta32 allele prevalence also increased with the clinical severity of disease.
Medical subject headings
- Encephalitis, Tick-Borne
- Gene Deletion
- Genetic Predisposition to Disease
- Receptors, CCR5