Nogo receptor antagonizes p75NTR-dependent motor neuron death.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18182498.
- Also identified by DOI 10.1073/pnas.0703842105 and PMC identifier 2206606.
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Abstract
The Nogo-66 receptor (NgR) plays a critical role in restricting axon regeneration in the central nervous system. This inhibitory action is in part mediated by a neuronal receptor complex containing p75NTR, a multifunctional receptor also well known to trigger cell death upon binding to neurotrophins such as NGF. In the present study, we show that Pep4 and NEP1-40, which are two peptides derived from the Nogo-66 sequence that modulate NgR-mediated neurite outgrowth inhibition, prevent NGF-stimulated p75NTR-dependent death of cultured embryonic motor neurons. They also confer protection on spinal cord motor neurons after neonatal sciatic nerve axotomy. These findings demonstrate an as-yet-unknown function of NgR in maintaining neuronal survival that may be relevant for motor neuron development and degeneration.
Medical subject headings
- Cell Death
- Gene Expression Regulation
- Myelin Proteins
- Nerve Degeneration
- Receptors, Cell Surface
- Receptors, Nerve Growth Factor
- Sciatic Nerve