Is airway smooth muscle the "missing link" modulating airway inflammation in asthma?
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 18187748.
- Also identified by DOI 10.1378/chest.07-0262.
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Abstract
Airway smooth muscle (ASM) plays a central role in regulating bronchomotor tone in patients with asthma. New evidence, however, suggests that ASM may also orchestrate and perpetuate airway inflammation by promoting the recruitment, activation, and trafficking of inflammatory cells in the airways. This review addresses the immunomodulatory function of ASM and highlights how such function may have therapeutic implications in the management of asthma.
Medical subject headings
- Asthma
- Immunologic Factors
- Muscle, Smooth