How IRE1 reacts to ER stress.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 18191217.
- Also identified by DOI 10.1016/j.cell.2007.12.017.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The long-awaited structure of the effector portion of IRE1, the endoplasmic reticulum stress transducer, is published in this issue of Cell (Lee et al., 2008). This structure provides new insight into the mysterious coupling of kinase and endoribonuclease activities in the oldest, most-conserved branch of the unfolded protein response in eukaryotes.
Medical subject headings
- Endoplasmic Reticulum
- Membrane Glycoproteins
- Oxidative Stress
- Protein Serine-Threonine Kinases
- Saccharomyces cerevisiae Proteins
- Yeasts