BEN: a novel domain in chromatin factors and DNA viral proteins.
basic_science · Level V
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- Record sourced from PubMed, PMID 18203771.
- Also identified by DOI 10.1093/bioinformatics/btn007 and PMC identifier 2477736.
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Abstract
We report a previously uncharacterized alpha-helical module, the BEN domain, in diverse animal proteins such as BANP/SMAR1, NAC1 and the Drosophila mod(mdg4) isoform C, in the chordopoxvirus virosomal protein E5R and in several proteins of polydnaviruses. Contextual analysis suggests that the BEN domain mediates protein-DNA and protein-protein interactions during chromatin organization and transcription. The presence of BEN domains in a poxviral early virosomal protein and in polydnaviral proteins also suggests a possible role for them in organization of viral DNA during replication or transcription.
Medical subject headings
- Chromatin
- Chromosomal Proteins, Non-Histone
- DNA Viruses
- Viral Proteins