Ral GTPases and cancer: linchpin support of the tumorigenic platform.
review · Level V
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- Record sourced from PubMed, PMID 18219307.
- Also identified by DOI 10.1038/nrc2296.
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Abstract
A confluence of recent observations has indicted the Ras-family G-proteins RALA and RALB as key offenders in the subversion of core biological systems driving oncogenic transformation. Here, we will focus on current developments highlighting the pivotal contribution of Ral proteins to the regulatory framework supporting tumorigenesis, and evaluate mechanistic connections between Ral effector activation and generation of this framework.
Medical subject headings
- Gene Expression Regulation, Enzymologic
- Gene Expression Regulation, Neoplastic
- Neoplasms
- ral GTP-Binding Proteins