Human embryonic stem cell derivation from poor-quality embryos.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 18223642.
- Also identified by DOI 10.1038/nbt1378.
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Abstract
During in vitro fertilization, embryos deemed clinically useless based on poor morphology are typically discarded. Here we demonstrate a statistical correlation between the developmental stage of such poor-quality embryos and the yield of human embryonic stem (hES) cell lines. Early-arrested or highly fragmented embryos only rarely yield cell lines, whereas those that have achieved blastocyst stage are a robust source of normal hES cells.
Medical subject headings
- Cell Culture Techniques
- Embryo, Mammalian
- Embryonic Stem Cells